In 2013, 1 billion prescriptions, or 58 percent of all prescriptions, were routed electronically.

E-prescribing cuts medical transaction costs by eliminating the need for confirmation phone calls and faxes, and reduces health risks associated with prescription delays. In 2004, over half of states had legislation banning e-prescribing. Today, all 50 states allow it, and many have begun to actively promote the practice. In 2011, Minnesota became the first state to pass an e-prescribing mandate to encourage adoption. Likewise, South Dakota adopted a program to incentivize electronic record-keeping in 2008. Moreover, in 2013, 47 states had over a third of prescriptions filled electronically, up from just 23 in 2011.